Buffalo’s Week 4 win over New Orleans highlighted a balanced Bills offense, led by James Cook’s 86.6 PFF grade and supported by a solid interior line and reliable targets. The five top grades—Cook (RB), Van Demark (OL), Palmer (WR), Edwards (OL), and Shakir (WR)—underscore a versatile attack that should keep fantasy managers optimistic about weekly upside and multiple path to points.

Cook’s elite grade anchors fantasy lineups as a high-end RB2/low-end RB1 with continued workhorse potential. Palmer and Shakir appear as dependable mid-range flex options, while Edwards and Van Demark reinforce Bills’ run game and pass protection. If Buffalo maintains this balance, the offense could sustain strong fantasy output even when Diggs is drawing heavy attention.

Denver's offensive line vaults to No. 1 after a Week 4 performance that yielded six pressures and zero sacks on 45 pass plays, driving a 93.3 PFF pass-blocking efficiency that sits among the league’s elite. Bolles leads the unit with an 88.1 overall grade, while Powers and Meinerz anchor the interior with exceptional pass-game consistency. Week 5 projections reinforce the starting five of Bolles, Powers, Wattenberg, Meinerz, and McGlinchey as a unit that fantasy managers should watch closely.

Buffalo rises with strong run protection and a revamped forward wall. Van Demark’s 82.0 run-blocking grade tops the Bills, complemented by Edwards’ 75.3 overall grade and Dawkins’ 77.8, both ranking highly among guards and tackles. The shift comes as Cincinnati’s defense faced a tougher challenge and Philly’s line wobbled, underscoring how weekly OL play shapes fantasy output for both quarterbacks and backs in a league where clean pockets remain king.

Buffalo’s James Cook is again the focal point of a high-octane Bills offense after signing a four-year, $48 million extension. He leads the league in rushing TDs with five through four games, while averaging 5.3 yards per carry and snagging 12 of 13 targets from Josh Allen. A Week 4 explosion—25 touches, 135 yards, a TD—earned the top PFF grade for Buffalo. With Allen thriving, Buffalo eyes a 5-0 start in primetime against New England, and Cook’s red-zone workload remains fantasy-friendly even as expectations stay sky-high.